Description
A multi-kinase inhibitor; inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ (IC50s = 1.5, 2.5, 4.2, 7, 13, and 22 nM, respectively); inhibits B-RAF, VEGFR3, FGFR, and Tie2 (IC50s = 28, 46, 202, and 311 nM, respectively); reduces tumor size in the MDA-MB-231 breast and 786-O renal cancer mouse xenograft models at 10 mg/kg; reduces tumor microvessel area and inhibits tumor growth in a panel of mouse xenograft models